Non-invasive Imaging to Guide Percutaneous Coronary Revascularization in Chronic Total Occlusion: a Systematic Review and Meta-Analysis

ESC 2024, London

A companion to the on-site study presentation
cmr
chronic total occlusion
meta-analysis
systematic review
Author
Affiliation

G. Bisaccia

Royal Brompton and Harefield Hospitals, London, UK

Published

July 2024

Please refer to the study poster for the full list of authors contributing to this work.

PRISMA Flow diagram

Characteristics of included studies

Included studies are described in Table 1.

Table 1: Baseline characteristics in included studies.
Authors Year Design Sample size Follow-up (months) Modality
Werner et al. (EuroCTO) (1) (2)

2023

2018

 RCT 396 37 Mixed
De Winter et al. (3) 2022 NROS 164 3 PET
Zhang et al. (4) 2022 NROS 55 12 CMR
Song et al. (5) 2021 NROS 2659 60 PET
Shokry et al. (6) 2021 NROS 48 6 CMR
Schumacher et al. (7) 2021 NROS 212 34 PET
Schumacher et al. (8) 2021 NROS 132 3 CMR
Everaars et al. (9) 2021 NROS 150 3 CMR
Vitadello et al. (10) 2020 NROS 49 4 Mixed
Umeji et al. (11) 2020 NROS 42 18 SPECT
Lee et al. (12) (DECISION-CTO) 2019 RCT 834 48 Mixed
Schumacher et al. (13) 2019 NROS 92 NR PET
Obedinskiy et al. (14)
(IMPACTOR-CTO)		 2018 RCT 94 12 CMR
Mashayekhi et al. (15) (REVASC) 2018 RCT 205 12 CMR
Galassi et al. (16) 2017 NROS 839 16 Mixed
Stuijfzand et al. (17) 2017 NROS 69 3 PET
Henriques et al. (18), Elias et al. (19), Elias et al. (20) (EXPLORE)
 2016-2018 RCT 180 4 CMR
Bucciarelli-Ducci et al. (21) 2016 NROS 32 3 CMR
Rossello et al. (22) 2016 NROS 47 6 CMR
Cardona et al. (23) 2016 NROS 32 6 CMR
Chadid et al. (24) 2015 NROS 43 9 CMR
Roifman et al. (25) 2013 NROS 30 5 CMR
Pujadas et al. (26) 2013 NROS 33 6 CMR
Borgia et al. (27) 2012 NROS 302 48 CMR
Sun et al. (28) 2012 NROS 99 12 SPECT
Kirschbaum et al. (29) 2012 NROS 43 6 CMR
Safley et al. (30) 2011 NROS 301 12 Mixed
Kirschbaum et al. (31) 2008 NROS 21 32 CMR
Cheng et al. (32) 2008 NROS 17 6 CMR
Heyne et al. (33) 2007 NROS 13 5 CMR
Baks et al. (34) 2006 NROS 27 5 CMR

MVD, multivessel disease; NR, data not reported; NROS, nonrandomized observational study; RCT, randomized clinical trial. For RCTs on CTO-PCI, J-CTO score refers to the PCI cohort. For referenced publications reporting on the same cohort, different outcomes were extracted from each.

Primary endpoint

The forest plot shows the incidence rates along with the pooled estimate for the primary composite endpoint of all-cause death and nonfatal myocardial infarction from all studies reporting these as outcomes.

The forest plot shows the incidence rates along with the pooled estimate for the primary composite endpoint of all-cause death and nonfatal myocardial infarction from all studies reporting these as outcomes.

Secondary composite endpoint

Forest plot for the incidence of the secondary composite endpoint of CV death, nonfatal MI and TVR.

Forest plot for the incidence of the secondary composite endpoint of CV death, nonfatal MI and TVR.

Change in angina burden

Forest plot for change in Seattle Angina Questionnaire summary score following CTO-PCI. SMD, standardized mean difference.

Forest plot for change in Seattle Angina Questionnaire summary score following CTO-PCI. SMD, standardized mean difference.

References

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