Evidence Synthesis & Health Economics Consulting
I deliver rigorous evidence synthesis and economic evaluations that inform healthcare decisions and have real-world impact.
- My systematic review in JAMA Cardiology has been incorporated into the ESC Clinical Guidelines and cited 18+ times.
- My two sister systematic reviews on risk of Guillain-Barré syndrome after COVID-19 and COVID-19 vaccination have been cited 35+ times.
- I have presented my research at 10+ international cardiovascular conferences in Europe and the USA.
Credentials:
- MD-PhD, G. d’Annunzio University, Italy
- MSc Health Economics, Outcomes and Management in Clinical Sciences, London School of Economics (LSE), UK (class of 2025)
- 21+ peer-reviewed publications in leading journals
- As a research officer at LSE Health, I am currently developing economic evaluation tools for EU-funded HYPERMARKER project
Evidence Synthesis
Transform scattered research into clear, actionable insights through systematic and transparent methodology and reporting.
Systematic Reviews
PRISMA-compliant comprehensive evidence assessment
- Applications: grant applications, clinical guidelines, competitive landscape analysis, regulatory submissions
- Deliverables: Protocol with PROSPERO registration, full manuscript, PRISMA flow diagram, quality assessment, evidence tables
- Timeline: 8-12 weeks
- See published examples
Meta-Analysis
Statistical synthesis for precise effect estimates
- Applications: Publications, research synthesis, demonstrating product superiority, market access dossiers
- Expertise: Fixed/random effects models, subgroup analysis, meta-regression, publication bias assessment
- Deliverables: Forest plots, funnel plots, sensitivity analyses, technical reports
- See published examples
Network Meta-Analysis
Compare multiple interventions simultaneously
- Applications: Treatment rankings for guidelines, indirect comparisons for HTA, competitive positioning
- Methods: Bayesian and frequentist approaches, consistency assessment, GRADE certainty ratings
- Deliverables: Network plots, league tables, SUCRA rankings, comprehensive reports
Health Economics and Outcomes Research
Quantify value propositions and optimize healthcare resource allocation with advanced economic modeling.
Cost-Effectiveness Analysis
Full economic evaluation for decision-making
- Applications: Reimbursement submissions, formulary applications, pricing strategy, policy evaluation
- Modeling: Markov models, decision trees, discrete event simulation, partitioned survival
- Outputs: ICERs, cost-effectiveness planes, acceptability curves, value of information analysis
Budget Impact Analysis
Real-world affordability and resource planning
- Applications: Hospital formulary decisions, payer negotiations, healthcare planning
- Capabilities: Multi-year projections, scenario analysis, population modeling
- Deliverables: Excel-based models, executive summaries, presentation decks
Survival Analysis
Time-to-event modeling and extrapolation
- Applications: Overall survival, progression-free survival, lifetime cost projections
- Methods: Kaplan-Meier, Cox regression, parametric survival models, flexible spline models
- Software: R (survival, flexsurv packages)
Decision Curve Analysis
Clinical utility assessment for predictive models
- Applications: Biomarker evaluation, risk prediction models, diagnostic test evaluation
- Deliverables: Net benefit curves, clinical impact plots, decision thresholds
Interactive Data Visualization
Transform complex analyses into intuitive, interactive experiences with custom Shiny applications.
R/Shiny Dashboard Development
Interactive tools that bring your data to life
I create custom interactive dashboards that enable real-time exploration of:
- Clinical Trial Data: Interactive sample size calculations with power analysis
- Diagnostic Test Evaluation: Dynamic diagnostic accuracy assessments with ROC curves
- Economic Models: Sensitivity analysis dashboards for cost-effectiveness results
- Evidence Synthesis: Interactive forest plots and network visualizations
Technical Expertise: R/Shiny, reactive programming, custom UI/UX design, deployment to ShinyApps.io or private servers
Deliverables: Fully functional web applications, source code, deployment support, user documentation
Research Support Services
Enhance your research quality and impact with expert review and professional medical writing.
Critical Document Review
Expert assessment to strengthen your research outputs
I provide thorough critical review and constructive feedback for:
- Grant Applications: Methodology, feasibility, and impact assessment
- Research Proposals: Study design, statistical planning, and coherence
- Study Protocols: PROSPERO registrations, ethics applications, analysis plans
- Manuscripts: Pre-submission review for clarity, methodology, and journal fit
Deliverables: Detailed written feedback, track-changes document, strategic recommendations
Medical Writing Services
Professional writing that communicates complex research clearly
- Systematic Review Manuscripts: Full manuscript preparation from protocol to submission
- Technical Reports: HTA dossiers, white papers, evidence summaries
- Grant Writing Support: Methodology sections, statistical analysis plans
- Regulatory Documents: Clinical study reports, regulatory submissions
Expertise: Publication in high-impact journals, adherence to reporting guidelines (PRISMA, STROBE, CONSORT)